maximum tolerated dose meaning in Hindi

Examples

1. Maximum tolerated dose studies are also done in clinical trials.
2. In the Phase 1b trials shows the safety and pharmacokinetics that help decide what the maximum tolerated dose is.
3. Also, how would you want to compare them-the number of pills, the maximum tolerated dose, or some other measure?
4. In the first human study of BIBW 2992, the maximum tolerated dose in a two-week-on, two-week off schedule was 70 mg once-daily.
5. This is generally defined by the range between the minimum effective dose ( MED ) and the maximum tolerated dose ( MTD ).
6. Following inconclusive VEGF-C, circulating endothelial cells, and CD146 and CD34 / 133 counts, and a maximum tolerated dose has still not been established.
7. Moreover, the first step in testing ordinary chemotherapy is to check for the maximum tolerated dose _ the amount that stops just short of killing the patient.
8. In a phase I study of 25 patients with advanced solid tumours, BIBF 1120 showed a favourable safety and pharmacokinetic profile with a maximum tolerated dose of 250mg.
9. In another phase I dose-escalation study, in 22 patients with advanced gynaecological malignancies, the maximum tolerated dose of BIBF 1120 twice-daily combined with paclitaxel and carboplatin was 200mg.
10. A maximum tolerated dose of aldoxorubicin has been established at 3.5 times the MTD of doxorubicin, and studies have indicated increased response rates for patients with soft tissue sarcomas.